Lilly Drug May Shorten COVID-19 Recovery Time

Indianapolis-based Eli Lilly and Co. (NYSE: LLY) says it is starting to see
positive results in clinical trials in the fight against COVID-19 by using
one of its drugs already approved for rheumatoid arthritis.

The company says it is seeing shorter hospital stays in patients who are
treated with its RA medication baricitinib in conjunction with remdesivir in
hospitalized patients with COVID-19.

Lilly said the combination of the two medications has shortened by one day
the recovery time for hospitalized patients.

Gilead Sciences, which manufactures the
<stories.gilead.com/articles/an-open-letter-from-daniel-oday-june-29>
antiviral medication remdesivir, is conducting its own COVID-19 study
evaluating the efficacy of its drug, as a standalone treatment. Gilead said
the results show a reduced recovery time by an average of four days.

The Lilly study, which is being conducted by the National Institute of
Allergy and Infectious, includes more than 1,000 patients who were
hospitalized with COVID-19. Lilly entered into the double-blind,
placebo-controlled clinical trial in May 2020.

“I think we’ve made a huge step compared to where we were in just the month
of March,” said Patrik Jonsson, Lilly senior vice president and president of
Lilly Bio-Medicines.

Baricitinib is marketed commercially as Olumiant and is used to treat
patients with rheumatoid arthritis. Lilly licensed the medication from
Delaware-based pharmaceutical Incyte Corp. (Nasdaq: INCY)

The company said the one-day reduction in median recovery time is
“statistically significant.”

“There is an urgent need to identify COVID-19 treatments, and we will
continue to work with NIAID to understand these data and next steps on
baricitinib’s role moving forward,” said Jonsson in a news release. “We
appreciate NIAID selecting baricitinib for inclusion in this important study
and the participants, investigators and collaborators for the vital roles
they played.”

Lilly defines recovery as a participant being well enough for hospital
discharge, meaning the participant either no longer required supplemental
oxygen or ongoing medical care in the hospital.

The U.S. Food and Drug Administration has already issued an Emergency Use
Authorization for remdesivir for the treatment of COVID-19.

Jonsson said based on the new findings, Lilly plans to discuss with the FDA
the potential for an EUA.

If authorized for use, Lilly will propose that baricitinib be available
through commercial channels.

Last week,
<www.insideindianabusiness.com/story/42608765/lilly-promotes-two-exe
cutives> Jonsson was named president of Lilly USA. The promotion is
effective October 1.

Source: Inside Indiana Business with Gerry Dick

Photo courtesy of Eli Lilly & Co.